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Australian Government: National Measurement InstituteAustralian Government: National Measurement Institute
National Measurement Institute
      

Indicative Project

Use of XRF in the pharmaceutical industry

Background Info

​X-ray Fluorescence (XRF) analysis is an excellent complement to other high-level elemental analysis techniques such as Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES). Advantages of XRF include rapid analysis without the need for sample digestion and excellent reproducibility in many situations. These features make XRF potentially attractive for monitoring product quality in pharmaceutical production.

Project Description

​The objective of this project is to assess the capability and performance of an XRF unit in analysing different types of pharmaceutical samples including raw materials and finished products with a focus on the quantification of some compounds such as TiO2 and SiO2 that are difficult to digest with acids.

This project will consider the theory of XRF, its advantages and limitations. Sample assessment will be designed to reflect the requirements and regulations of the pharmaceutical industry. The XRF analysis results will be compared with those from other techniques such as ICP-OES.

Examples of Relevant Sudent Courses

Analytical Chemistry, Inorganic Chemistry, Organic Chemistry

Student Level

Honours, Masters

Duration

1 year

Location

North Ryde (NSW)

Section

Analytical Services, Chemical & Biological Metrology

Contact

Andrew Evans

Email Contact

andrew.evans@measurement.gov.au

Interested in this project?

Application Form